VUITY pilocarpine

Drug Class

Cholinergic agonist / Muscarinic receptor agonist

Mechanism

Pilocarpine is a cholinergic agonist that binds to muscarinic receptors on smooth muscles, causing pupillary constriction (miosis) to improve near visual acuity through the pinhole effect.

Approved Indication

Treatment of presbyopia in adults.

What This Means For Patients

VUITY is not distributed through mainland China's retail pharmacy network. Uwell Cloud can help arrange a purchase channel for this medicine, sourced and dispatched from Hong Kong; clinical administration support in China can be coordinated on request. Availability and eligibility for any specific patient are determined by clinical review.

Regulatory Approvals

• FDA — Approved (2021) — Sources

Pivotal Clinical Evidence

• GEMINI 1 — Waring et al., JAMA Ophthalmol 2022 (NCT03804268) — Sources

Sources

• https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/214094s000lbl.pdf
• https://news.abbvie.com/news/press-releases/vuity-pilocarpine-hci-ophthalmic-solution-125-first-and-only-fda-approved-eye-drop-for-treatment-presbyopia-is-now-available.htm